With constant changes in HRSA’s “expectations”, “recommendations” and audit focus, implementation and ongoing compliance of hospital and grantee’s 340B programs can be an arduous task, and also a moving target. RPh Innovations (RPHI), a 340B Program Support and Independent Auditor established in 2011, will re-center the focus around core statues and regulatory concepts of the program, and outline action items to help attendees start implementing structure, policy, and delegation of responsibilities within their respective institutions.